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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DYRK2
All Species:
28.48
Human Site:
T578
Identified Species:
44.76
UniProt:
Q92630
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q92630
NP_003574.1
601
66652
T578
S
S
A
S
K
L
R
T
N
L
A
Q
M
T
D
Chimpanzee
Pan troglodytes
XP_509205
601
66595
T578
S
S
A
S
K
L
R
T
N
L
A
Q
M
T
D
Rhesus Macaque
Macaca mulatta
XP_001117134
601
66643
T578
S
S
A
S
K
L
R
T
N
L
A
Q
M
T
D
Dog
Lupus familis
XP_538273
601
66656
T578
S
S
A
S
K
L
R
T
N
L
A
Q
M
T
D
Cat
Felis silvestris
Mouse
Mus musculus
Q5U4C9
599
66538
T576
S
S
A
S
K
L
R
T
N
L
A
Q
M
T
D
Rat
Rattus norvegicus
Q4V8A3
586
65492
L563
V
V
G
I
A
S
K
L
K
A
N
L
M
S
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511087
546
60615
T523
S
G
S
A
K
L
R
T
S
L
A
Q
M
T
D
Chicken
Gallus gallus
Q5ZIU3
526
59419
N504
S
A
S
K
L
R
T
N
L
A
Q
M
T
D
A
Frog
Xenopus laevis
NP_001088793
567
63329
L544
V
V
G
V
G
N
K
L
R
A
N
L
M
N
D
Zebra Danio
Brachydanio rerio
NP_001038298
587
65453
T564
G
S
A
T
K
L
R
T
N
L
A
Q
M
T
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P83102
828
92722
S632
F
A
A
E
T
T
A
S
S
T
S
A
T
S
I
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_001023208
796
87422
W773
A
Q
A
L
K
H
K
W
L
R
R
R
L
P
N
Sea Urchin
Strong. purpuratus
XP_799140
561
63192
P538
S
S
A
V
S
K
L
P
P
T
G
A
A
G
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P51566
467
54180
R445
L
N
H
P
F
F
T
R
S
R
E
Q
S
I
P
Baker's Yeast
Sacchar. cerevisiae
P14680
807
91227
V765
A
T
G
G
A
D
S
V
D
I
G
A
I
S
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.5
99.6
98.3
N.A.
97
59.7
N.A.
78.6
81.3
64.5
83.6
N.A.
43.3
N.A.
45.7
63.7
Protein Similarity:
100
98.8
99.8
99
N.A.
98.5
71.8
N.A.
83
84.5
75
89.8
N.A.
54.9
N.A.
55.6
73.5
P-Site Identity:
100
100
100
100
N.A.
100
6.6
N.A.
73.3
6.6
13.3
86.6
N.A.
6.6
N.A.
13.3
20
P-Site Similarity:
100
100
100
100
N.A.
100
26.6
N.A.
93.3
20
20
93.3
N.A.
40
N.A.
46.6
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.3
27.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
36.6
41.2
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
14
14
60
7
14
0
7
0
0
20
47
20
7
0
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
7
0
0
7
0
0
0
0
7
54
% D
% Glu:
0
0
0
7
0
0
0
0
0
0
7
0
0
0
7
% E
% Phe:
7
0
0
0
7
7
0
0
0
0
0
0
0
0
0
% F
% Gly:
7
7
20
7
7
0
0
0
0
0
14
0
0
7
0
% G
% His:
0
0
7
0
0
7
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
7
0
0
0
0
0
7
0
0
7
7
7
% I
% Lys:
0
0
0
7
54
7
20
0
7
0
0
0
0
0
14
% K
% Leu:
7
0
0
7
7
47
7
14
14
47
0
14
7
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
7
60
0
0
% M
% Asn:
0
7
0
0
0
7
0
7
40
0
14
0
0
7
7
% N
% Pro:
0
0
0
7
0
0
0
7
7
0
0
0
0
7
7
% P
% Gln:
0
7
0
0
0
0
0
0
0
0
7
54
0
0
0
% Q
% Arg:
0
0
0
0
0
7
47
7
7
14
7
7
0
0
0
% R
% Ser:
54
47
14
34
7
7
7
7
20
0
7
0
7
20
0
% S
% Thr:
0
7
0
7
7
7
14
47
0
14
0
0
14
47
0
% T
% Val:
14
14
0
14
0
0
0
7
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _